| Data file S6.1. Differentially expressed genes identified in Pt-msx1 pRNAi and RNA-seq
at late stage 5 |
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| adapted from
Akiyama-Oda and Oda, Sci. Adv. 6, eaba7261 (2020) |
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| under a Creative Commons
Attribution License 4.0 (CC BY 4.0) |
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| aug3 gene model |
logFC(msx5) |
FDR(msx5) |
logFC(hh5) |
FDR(hh5) |
logFC(ptc5) |
FDR(ptc5) |
logFC(gfp5) |
FDR(gfp5) |
logFC(msx6) |
FDR(msx6) |
link to Genome browser |
NCBI Gene ID (link to NCBI) |
Accession |
Protein |
Symbol |
E-value |
Accession |
Protein |
Symbol |
E-value |
| aug3.g20540 |
-4.17492208 |
6.31E-33 |
3.460588806 |
8.65E-18 |
2.753212136 |
0.094580418 |
3.206656586 |
8.49E-11 |
-1.47015404 |
0.393065412 |
aug3.g20540 |
|
sp|P58958|G39AC_DROME |
Gustatory and pheromone receptor
39a, isoform D |
Gr39a |
3.6 |
tr|I7HPB4|I7HPB4_HUMAN |
Fukutin (Fragment) |
FKTN |
1.4 |
| aug3.g1120 |
-2.17490019 |
8.97E-15 |
-1.16546478 |
0.087417633 |
-0.25177105 |
0.631171504 |
-0.77151786 |
0.01254865 |
-1.64716562 |
6.66E-08 |
aug3.g1120 |
LOC107445673 |
tr|Q9W2S2|Q9W2S2_DROME |
Autophagy-specific
gene 8a, isoform A |
Atg8a |
4.00E-15 |
sp|Q9BXW4|MLP3C_HUMAN |
Microtubule-associated
proteins 1A/1B light chain 3C |
MAP1LC3C |
2.00E-22 |
| aug3.g3016 |
-5.74691468 |
8.16E-09 |
5.539798955 |
6.03E-31 |
NA |
NA |
-1.18544512 |
0.659339889 |
-1.61792064 |
0.593970065 |
aug3.g3016 |
LOC107449920 |
sp|P41375|IF2B_DROME |
Eukaryotic
translation initiation factor 2 subunit 2 |
eIF-2beta |
2.00E-71 |
sp|P20042|IF2B_HUMAN |
Eukaryotic
translation initiation factor 2 subunit 2 |
EIF2S2 |
4.00E-72 |
| aug3.g16171 |
-2.16705199 |
2.14E-07 |
-1.51728121 |
0.004166502 |
0.711743873 |
0.166919191 |
-0.7779588 |
0.013344082 |
-2.10265298 |
1.19E-06 |
aug3.g16171 |
LOC107441837 |
tr|Q7KRT4|Q7KRT4_DROME |
GH07253p |
stops |
3.00E-04 |
sp|Q8WXJ9|ASB17_HUMAN |
Ankyrin repeat
and SOCS box protein 17 |
ASB17 |
0.007 |
| aug3.g18439 |
-1.61194406 |
4.50E-07 |
-0.77722623 |
0.521280477 |
-0.36634325 |
0.378097408 |
-0.47244732 |
0.200454206 |
-1.35278794 |
0.000362701 |
aug3.g18439 |
LOC107445281 |
tr|Q9W2S2|Q9W2S2_DROME |
Autophagy-specific
gene 8a, isoform A |
Atg8a |
2.00E-16 |
sp|Q9BXW4|MLP3C_HUMAN |
Microtubule-associated
proteins 1A/1B light chain 3C |
MAP1LC3C |
2.00E-23 |
| aug3.g18441 |
-1.9879967 |
5.51E-07 |
-1.0728794 |
0.160430818 |
-0.03971893 |
0.979776149 |
-0.63017302 |
0.176958665 |
-1.17869641 |
0.201095563 |
aug3.g18441 |
LOC107445279 |
tr|C4XVF5|C4XVF5_DROME |
MIP10388p
(Fragment) |
CG10559-RB |
6.3 |
sp|Q9HC84|MUC5B_HUMAN |
Mucin-5B |
MUC5B |
2.4 |
| aug3.g15216 |
-1.46756353 |
1.62E-06 |
-0.53860151 |
0.596136507 |
-1.21337706 |
1.48E-08 |
-0.41234148 |
0.266689301 |
-0.85131495 |
0.005677334 |
aug3.g15216 |
LOC107447958 |
tr|Q9VGY8|Q9VGY8_DROME |
CG14688 |
CG14688 |
9.00E-71 |
sp|Q5SRE7|PHYD1_HUMAN |
Phytanoyl-CoA
dioxygenase domain-containing protein 1 |
PHYHD1 |
2.00E-76 |
| aug3.g11206 |
1.417372346 |
3.32E-06 |
NA |
NA |
-2.23661046 |
1.51E-08 |
0.853218781 |
0.195684802 |
1.998297826 |
2.04E-07 |
aug3.g11206 |
LOC107457468 |
sp|Q9VC44|ALLS_DROME |
Allatostatin-A |
AstA |
0.002 |
sp|O95613|PCNT_HUMAN |
Pericentrin |
PCNT |
1.2 |
| aug3.g1121 |
-1.42097419 |
5.37E-05 |
-0.6997623 |
0.359220287 |
0.387978547 |
0.348591712 |
0.058548679 |
0.938236204 |
-1.03952266 |
0.048984154 |
aug3.g1121 |
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sp|Q0KHU5|PCAT1_DROME |
1-acylglycerophosphocholine
O-acyltransferase 1 |
CG32699 |
1.3 |
sp|O14646|CHD1_HUMAN |
Chromodomain-helicase-DNA-binding
protein 1 |
CHD1 |
3.4 |
| aug3.g8877 |
3.38377195 |
6.49E-05 |
NA |
NA |
NA |
NA |
NA |
NA |
2.997567724 |
2.03E-05 |
aug3.g8877 |
LOC107456846 |
sp|Q24048|ATPB2_DROME |
Sodium/potassium-transporting
ATPase subunit beta-2 |
nrv2 |
5.00E-30 |
sp|P05026|AT1B1_HUMAN |
Sodium/potassium-transporting
ATPase subunit beta-1 |
ATP1B1 |
9.00E-13 |
| aug3.g12949 |
1.131801157 |
0.0001773 |
4.207083427 |
4.23E-10 |
0.055110744 |
0.920932058 |
-0.24177878 |
0.717758319 |
0.693532753 |
0.129247029 |
aug3.g12949 |
LOC107438252 |
tr|Q9GNE3|Q9GNE3_DROME |
Hexokinase-C |
Hex-C |
1.00E-05 |
sp|P19367|HXK1_HUMAN |
Hexokinase-1 |
HK1 |
6.00E-09 |
| aug3.g25064 |
-1.36329465 |
0.000311979 |
-0.62210792 |
0.318825027 |
-0.28826903 |
0.520371326 |
0.410959661 |
0.586337257 |
-1.20436903 |
0.00354935 |
aug3.g25064 |
LOC107455476 |
tr|Q9VR28|Q9VR28_DROME |
CG15629 |
CG15629-RA |
9.00E-79 |
sp|Q8N3Y7|RDHE2_HUMAN |
Epidermal
retinol dehydrogenase 2 |
SDR16C5 |
4.00E-88 |
| aug3.g1123 |
-1.91393404 |
0.000652526 |
-0.74727563 |
0.012587057 |
-0.43662391 |
0.386412421 |
-0.33506558 |
0.548095917 |
-1.87845686 |
1.09E-05 |
aug3.g1123 |
LOC107445674 |
sp|P45447|E78C_DROME |
Ecdysone-induced
protein 78C |
Eip78C |
3.1 |
sp|P09923|PPBI_HUMAN |
Intestinal-type
alkaline phosphatase |
ALPI |
0.23 |
| aug3.g6266 |
-2.17204463 |
0.000652526 |
NA |
NA |
-0.53013352 |
0.488826623 |
-0.02111883 |
0.983844352 |
-1.67809421 |
0.073032935 |
aug3.g6266 |
LOC107454440 |
sp|P92177|1433E_DROME |
14-3-3 protein
epsilon |
14-3-3epsilon |
0.07 |
sp|P0C628|O5AC1_HUMAN |
Olfactory
receptor 5AC1 |
OR5AC1 |
0.49 |
| aug3.g16372 |
-1.1608335 |
0.000652526 |
-1.2203872 |
0.000492398 |
-0.27680034 |
0.540400776 |
-0.29275333 |
0.464031121 |
-1.48825212 |
5.48E-08 |
aug3.g16372 |
LOC107442125 |
sp|P48596|GCH1_DROME |
GTP
cyclohydrolase 1 |
Pu |
1.00E-86 |
sp|P30793|GCH1_HUMAN |
GTP
cyclohydrolase 1 |
GCH1 |
4.00E-96 |
| aug3.g11669 |
-1.09292607 |
0.0010407 |
-1.1754411 |
7.39E-06 |
-1.18893136 |
7.02E-06 |
-0.77880066 |
0.039151912 |
-1.23108604 |
3.03E-05 |
aug3.g11669 |
LOC107436573 |
sp|P02255|H1_DROME |
Histone H1 |
His1 |
9.00E-26 |
sp|P07305|H10_HUMAN |
Histone H1.0 |
H1F0 |
6.00E-11 |
| aug3.g16806 |
1.023415029 |
0.0010407 |
1.57598302 |
0.0641466 |
0.052947279 |
0.925239227 |
-0.33142541 |
0.561534182 |
0.6391059 |
0.243731233 |
aug3.g16806 |
LOC110283236 |
NA |
NA |
NA |
NA |
sp|Q9Y2G0|EFR3B_HUMAN |
Protein EFR3
homolog B |
EFR3B |
4.8 |
| aug3.g23934 |
1.462945082 |
0.001330517 |
1.091824222 |
0.212451483 |
-0.03868329 |
0.970056931 |
0.869848284 |
0.05776313 |
1.74112658 |
2.02E-07 |
aug3.g23934 |
|
sp|Q24592|JAK_DROME |
Tyrosine-protein
kinase hopscotch |
hop |
1 |
sp|Q17RR3|LIPR3_HUMAN |
Pancreatic
lipase-related protein 3 |
PNLIPRP3 |
1.4 |
| aug3.g11804 |
-0.83248306 |
0.001475607 |
-0.45711929 |
0.095131747 |
-0.16542368 |
0.472262992 |
-0.00648739 |
0.990004651 |
-0.73910545 |
0.003050507 |
aug3.g11804 |
LOC107436745 |
sp|Q9XZJ4|PSA6_DROME |
Proteasome
subunit alpha type-6 |
Prosalpha1 |
7.00E-69 |
sp|P60900|PSA6_HUMAN |
Proteasome
subunit alpha type-6 |
PSMA6 |
5.00E-80 |
| aug3.g24345 |
-4.94143645 |
0.001916575 |
3.386291722 |
0.010317846 |
NA |
NA |
NA |
NA |
-2.931492 |
0.08005103 |
aug3.g24345 |
|
tr|Q8T043|Q8T043_DROME |
CG3409, isoform
A |
CG3409-RA |
3.00E-04 |
tr|I3L431|I3L431_HUMAN |
Monocarboxylate
transporter 11 (Fragment) |
SLC16A11 |
8.00E-04 |
| aug3.g24992 |
-1.92672879 |
0.003616313 |
1.288112339 |
0.009456321 |
0.530240587 |
0.325364788 |
0.024850476 |
0.978855169 |
-2.46301967 |
0.001502663 |
aug3.g24992 |
LOC107455075 |
sp|P18502|PTC_DROME |
Protein patched |
ptc |
3.9 |
sp|Q96AT9|RPE_HUMAN |
Ribulose-phosphate
3-epimerase |
RPE |
0.057 |
| aug3.g7139 |
0.846092187 |
0.005095448 |
-0.20680566 |
0.661366558 |
0.350977447 |
0.09680972 |
0.334630293 |
0.372126053 |
0.550428199 |
0.041575291 |
aug3.g7139 |
LOC107439252 |
tr|Q9W4X4|Q9W4X4_DROME |
Phosphatidylinositol
4-kinase III alpha, isoform C |
PI4KIIIalpha |
0 |
sp|P42356|PI4KA_HUMAN |
Phosphatidylinositol
4-kinase alpha |
PI4KA |
0 |
| aug3.g13148 |
-1.84074396 |
0.005095448 |
0.657983917 |
0.277612654 |
0.196438273 |
0.901508516 |
0.043992312 |
0.969035949 |
-1.55919524 |
0.018193562 |
aug3.g13148 |
LOC107438505 |
tr|Q9VNK5|Q9VNK5_DROME |
CG10280 |
CG10280 |
1.00E-34 |
sp|O43897|TLL1_HUMAN |
Tolloid-like
protein 1 |
TLL1 |
2.00E-39 |
| aug3.g12244 |
-1.32576859 |
0.005095448 |
0.370041209 |
0.18679354 |
0.70487897 |
0.068145987 |
0.039707746 |
0.947703133 |
-0.66741196 |
0.024583135 |
aug3.g12244 |
LOC107437364 |
sp|Q24560|TBB1_DROME |
Tubulin beta-1
chain |
betaTub56D |
0 |
sp|Q9BVA1|TBB2B_HUMAN |
Tubulin beta-2B
chain |
TUBB2B |
0 |
| aug3.g25735 |
1.021218604 |
0.005095448 |
-0.28351597 |
0.796990641 |
-0.83167208 |
0.013040798 |
-0.19408689 |
0.709345371 |
1.216370381 |
7.77E-08 |
aug3.g25735 |
LOC107452633 |
tr|Q24413|Q24413_DROME |
Na/Ca exchange
protein |
Calx |
0 |
sp|P57103|NAC3_HUMAN |
Sodium/calcium
exchanger 3 |
SLC8A3 |
0 |
| aug3.g13305 |
-1.26157687 |
0.005095448 |
-1.80209507 |
3.67E-12 |
-0.10712703 |
0.799363586 |
0.008114836 |
0.99250331 |
-0.73163251 |
0.216777897 |
aug3.g13305 |
LOC107438702 |
tr|Q8SYC4|Q8SYC4_DROME |
CG13893 |
CG13893 |
1.00E-43 |
sp|O76054|S14L2_HUMAN |
SEC14-like
protein 2 |
SEC14L2 |
5.00E-67 |
| aug3.g3010 |
-1.25627127 |
0.005664323 |
1.552737127 |
4.99E-10 |
0.134040263 |
0.711456449 |
-0.42495537 |
0.111906229 |
-0.57495736 |
0.059767899 |
aug3.g3010 |
LOC107449871 |
sp|Q9VTI8|CHRB_DROME |
Protein charybde |
chrb |
8.00E-25 |
sp|Q96D03|DDT4L_HUMAN |
DNA
damage-inducible transcript 4-like protein |
DDIT4L |
5.00E-23 |
| aug3.g19881 |
-3.7615866 |
0.007958406 |
-0.47061528 |
0.852647776 |
NA |
NA |
-1.28040046 |
0.211159953 |
-2.02490328 |
3.59E-05 |
aug3.g19881 |
LOC107447639 |
tr|L0MPR7|L0MPR7_DROME |
Twin of eyeless,
isoform C |
toy |
4.00E-34 |
sp|P26367|PAX6_HUMAN |
Paired box
protein Pax-6 |
PAX6 |
8.00E-29 |
| aug3.g17399 |
-1.17916362 |
0.007958406 |
0.032240452 |
0.967654993 |
1.154737366 |
0.00051566 |
0.049979137 |
0.950365329 |
-1.28193545 |
4.43E-06 |
aug3.g17399 |
LOC107443684 |
sp|P84051|H2A_DROME |
Histone H2A |
His2A |
4.00E-53 |
sp|Q96QV6|H2A1A_HUMAN |
Histone H2A type
1-A |
HIST1H2AA |
2.00E-48 |
| aug3.g8813 |
-1.34618833 |
0.00972 |
0.791851687 |
0.086803393 |
-0.14370999 |
0.843885806 |
0.002348399 |
0.998153464 |
0.099029131 |
0.975939789 |
aug3.g8813 |
LOC107456767 |
tr|A4K7U3|A4K7U3_DROME |
Ctr1B (Fragment) |
Ctr1B |
2.00E-09 |
sp|O15431|COPT1_HUMAN |
High affinity
copper uptake protein 1 |
SLC31A1 |
7.00E-09 |
| aug3.g2708 |
-1.52677421 |
0.00016388 |
-2.39828366 |
1.97E-09 |
0.309078214 |
0.711111984 |
-0.72699802 |
0.0087767 |
-1.33467254 |
0.00423427 |
aug3.g2708 |
LOC107449344 |
tr|E3CTP3|E3CTP3_DROME |
RT10042p
(Fragment) |
CG14351-RA |
2.00E-13 |
sp|O75093|SLIT1_HUMAN |
Slit homolog 1
protein |
SLIT1 |
9.00E-11 |
| aug3.g9963 |
-1.26946222 |
0.0010407 |
0.877955361 |
0.058154924 |
1.083477114 |
8.22E-05 |
-0.84622722 |
6.23E-07 |
-1.53370134 |
0.001290904 |
aug3.g9963 |
LOC107443270 |
tr|Q9W0L6|Q9W0L6_DROME |
CG13907, isoform
A |
CG13907 |
1.00E-155 |
sp|Q6ZSM3|MOT12_HUMAN |
Monocarboxylate
transporter 12 |
SLC16A12 |
5.00E-41 |
| aug3.g27619 |
1.293258755 |
0.003773214 |
2.162155611 |
7.15E-09 |
0.610302696 |
0.016819886 |
0.880338806 |
0.008166134 |
1.08110734 |
4.11E-05 |
aug3.g27619 |
LOC107442388 |
tr|Q8MRF2|Q8MRF2_DROME |
GH04568p |
CG8312 |
8.00E-67 |
sp|Q8N2R8|FA43A_HUMAN |
Protein FAM43A |
FAM43A |
8.00E-32 |
| aug3.g18713 |
0.810391577 |
0.008019216 |
-0.79491709 |
0.310193191 |
0.745997246 |
0.044259238 |
1.180120685 |
0.009443317 |
0.968737422 |
0.001206358 |
aug3.g18713 |
LOC107445741 |
tr|Q7KJ08|Q7KJ08_DROME |
Alk |
Alk |
4.00E-07 |
sp|Q7Z304|MAMC2_HUMAN |
MAM
domain-containing protein 2 |
MAMDC2 |
1.00E-23 |
| aug3.g25139 |
-1.27839769 |
0.009477215 |
-1.16983044 |
0.001792179 |
-0.35434259 |
0.522655401 |
-0.74283269 |
0.00384649 |
-1.13038479 |
0.000430782 |
aug3.g25139 |
LOC110283034 |
sp|P98163|YL_DROME |
Putative
vitellogenin receptor |
yl |
0.088 |
sp|P98164|LRP2_HUMAN |
Low-density
lipoprotein receptor-related protein 2 |
LRP2 |
0.011 |
| aug3.g2785 |
-1.8342941 |
1.95E-06 |
-0.24000104 |
0.803260326 |
-0.18111079 |
0.855194006 |
-0.97390683 |
5.43E-06 |
-1.44683522 |
0.077764526 |
aug3.g2785 |
LOC107449457 |
tr|Q7KRT4|Q7KRT4_DROME |
GH07253p |
stops |
7.00E-04 |
sp|Q96NS5|ASB16_HUMAN |
Ankyrin repeat
and SOCS box protein 16 |
ASB16 |
0.006 |
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FDR < 0.01 in the
gfp pRNAi experiment at late stage 5 |
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