Table S1. Parasteatoda tepidariorum counterparts of Hedgehog signaling genes |
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adapted from
Akiyama-Oda and Oda, Sci. Adv. 6, eaba7261 (2020) |
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under a Creative Commons
Attribution License 4.0 (CC BY 4.0) |
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Parasteatoda tepidariorum |
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Drosophila melanogaster |
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Homo sapiens |
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Transcriptional response |
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Gene category |
aug3 gene model |
NCBI Gene ID |
e-value(blastx-Drosophila) |
Full Name |
Symbol |
NCBI Gene ID |
Full Name |
Symbol |
NCBI Gene ID |
to hh and ptc pRNAi*** |
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hedgehog |
aug3.g4322 |
LOC107451809 |
5.00E-114 |
hedgehog |
hh |
42737 |
Indian hedgehog
signaling molecule |
IHH |
3549 |
hh3(-), hh5(-) |
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aug3.g5978 |
LOC107454029 |
3.00E-89 |
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sonic hedgehog signaling molecule |
SHH |
6469 |
n |
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desert hedgehog signaling molecule |
DHH |
50846 |
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patched |
aug3.g14374 |
LOC107440240 |
9.00E-132 |
patched |
ptc |
35851 |
patched 1 |
PTCH1 |
5727 |
hh5(-), ptc3(-) |
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patched 2 |
PTCH2 |
8643 |
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smoothened |
aug3.g8490 |
LOC107456312 |
6.00E-125 |
smoothened |
smo |
33196 |
smoothened,
frizzled class receptor |
SMO |
6608 |
ptc5(+) |
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cubitus
interruptus |
aug3.g13321 |
LOC107438714 |
7.00E-90 |
cubitus interruptus |
ci |
43767 |
GLI family zinc
finger 3 |
GLI3 |
2737 |
hh5(+), ptc5(-) |
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GLI family zinc finger 2 |
GLI2 |
2736 |
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GLI family zinc finger 1 |
GLI1 |
2735 |
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Suppressor
of fused |
aug3.g4889 |
LOC107452674 |
3.00E-93 |
Suppressor of fused |
Su(fu) |
41565 |
SUFU negative
regulator of hedgehog signaling |
SUFU |
51684 |
n |
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fused |
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fused |
fu |
32855 |
serine/threonine
kinase 36 |
STK36 |
27148 |
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Costal2 |
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costa |
cos |
35653 |
kinesin family member 27 |
KIF27 |
55582 |
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kinesin family member 7 |
KIF7 |
374654 |
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Pka-C1 |
aug3.g8395 |
LOC107456224 |
0 |
Protein kinase, cAMP-dependent, catalytic subunit 1 |
Pka-C1 |
34284 |
protein kinase cAMP-activated catalytic subunit beta |
PRKACB |
5567 |
n |
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aug3.g19761 |
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0 |
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protein kinase cAMP-activated catalytic subunit alpha |
PRKACA |
5566 |
n |
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GSK3B |
aug3.g9959 |
LOC107443254 |
0 |
shaggy |
sgg |
31248 |
glycogen
synthase kinase 3 beta |
GSK3B |
2932 |
n |
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aug3.g25394 |
LOC107441379 |
0 |
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n |
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Casein kinase I |
aug3.g16082 |
LOC107441751 |
3.00E-169 |
Casein kinase
Ialpha |
CkIalpha |
32221 |
casein kinase 1
alpha 1 |
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1452 |
n |
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aug3.g14270 |
LOC107440109 |
1.00E-178 |
discs overgrown |
dco |
43673 |
casein kinase 1 epsilon |
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1454 |
n |
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casein kinase 1 delta |
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1453 |
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arrestin beta |
aug3.g2972 |
LOC107449817 |
0 |
kurtz |
krz |
53554 |
arrestin beta 1 |
ARRB1 |
408 |
n |
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Gprk2 |
aug3.g279 |
LOC107452617 |
0 |
G protein-coupled receptor kinase 2 |
Gprk2 |
49045 |
G
protein-coupled receptor kinase 5 |
GRK5 |
2869 |
hh3(+), hh5(-) |
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G protein-coupled receptor kinase 6 |
GRK6 |
2870 |
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G protein-coupled receptor kinase 4 |
GRK4 |
2868 |
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aug3.g19133 |
LOC107446386 |
0 |
G protein-coupled receptor kinase 1 |
Gprk1 |
3355013 |
G protein-coupled receptor kinase 3 |
GRK3 |
157 |
n |
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G protein-coupled receptor kinase 2 |
GRK2 |
156 |
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SPOP |
aug3.g12578 |
LOC107437781 |
0 |
roadkill |
rdx |
41704 |
speckle type
BTB/POZ protein |
SPOP |
8405 |
n |
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Rab23 |
aug3.g27635 |
LOC107442385 |
3.00E-37 |
Rab23 |
rab23 |
40701 |
RAB23, member
RAS oncogene family |
RAB23 |
51715 |
n |
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Talpid3 |
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KIAA0586 |
KIAA0586 |
9786 |
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tectonic* |
aug3.g2815 |
LOC107449540 |
2.00E-27 |
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tectonic family
member 1 |
TCTN1 |
79600 |
n |
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6.00E-27 |
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tectonic family member 3 |
TCTN3 |
26123 |
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DZIP1
(iguana) |
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DAZ interacting
zinc finger protein 1 |
DZIP1 |
22873 |
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slimb |
aug3.g5127 |
LOC107452997 |
0 |
supernumerary
limbs |
slmb |
42504 |
beta-transducin
repeat containing E3 ubiquitin protein ligase |
BTRC |
8945 |
n |
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aug3.g13225 |
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0 |
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F-box and WD repeat domain containing 11 |
FBXW11 |
23291 |
n |
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Cullin 1 |
aug3.g1917 |
LOC107447770 |
0 |
Cullin 1 |
Cul1 |
35742 |
cullin 1 |
CUL1 |
8454 |
n |
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aug3.g10620 |
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0 |
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n |
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Roc1a |
aug3.g6006 |
LOC107454093 |
2.00E-63 |
Regulator of
cullins 1a |
Roc1a |
31014 |
ring-box 1 |
RBX1 |
9978 |
n |
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Cullin 3 |
aug3.g4476 |
LOC107452044 |
0 |
Cullin 3 |
Cul3 |
34896 |
cullin 3 |
CUL3 |
8452 |
n |
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skinny
hedgehog |
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rasp |
rasp |
44098 |
hedgehog
acyltransferase |
HHAT |
55733 |
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tout-velu |
aug3.g3559 |
LOC107450714 |
0 |
tout-velu |
ttv |
36614 |
exostosin
glycosyltransferase 1 |
EXT1 |
2131 |
n |
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sister
of tout-velu |
aug3.g12248 |
LOC107437365 |
0 |
Ext2 |
Ext2 |
3772101 |
exostosin
glycosyltransferase 2 |
EXT2 |
2132 |
n |
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brother of tout-velu |
aug3.g6974 |
LOC107455291 |
0 |
brother of tout-velu |
botv |
37198 |
exostosin like glycosyltransferase 3 |
EXTL3 |
2137 |
n |
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dispatched |
aug3.g10365 |
LOC107448433 |
7.00E-180 |
dispatched |
disp |
44274 |
dispatched RND
transporter family member 1 |
DISP1 |
84976 |
n |
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dispatched RND transporter family member 2 |
DISP2 |
85455 |
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shifted |
aug3.g27568** |
LOC107442208 |
2.00E-47 |
shifted |
shf |
31617 |
WNT inhibitory
factor 1 |
WIF1 |
11197 |
hh5(+), ptc5(-) |
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aug3.g24611** |
LOC107442208 |
7.00E-24 |
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hh5(+), ptc5(-) |
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GAS1* |
aug3.g9575 |
LOC107438015 |
4.00E-14 |
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growth arrest
specific 1 |
GAS1 |
2619 |
hh5(+), ptc5(-) |
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dally |
aug3.g1222 |
LOC107446074 |
1.00E-56 |
division
abnormally delayed |
dally |
39013 |
glypican 5 |
GPC5 |
2262 |
n |
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dally-like |
aug3.g2730 |
LOC107449382 |
2.00E-77 |
dally-like |
dlp |
39596 |
glypican 6 |
GPC6 |
10082 |
n |
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aug3.g11833 |
LOC107436350 |
1.00E-55 |
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hh5(-), ptc5(+) |
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interference hedgehog |
aug3.g12323 |
LOC107437450 |
9.00E-64 |
brother of ihog |
boi |
31229 |
BOC cell
adhesion associated, oncogene regulated |
BOC |
91653 |
n |
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9.00E-50 |
interference hedgehog |
ihog |
33972 |
cell adhesion associated, oncogene regulated |
CDON |
50937 |
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HHIP |
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hedgehog
interacting protein |
HHIP |
64399 |
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Megalin |
aug3.g9796 |
LOC107441084 |
0 |
Megalin |
mgl |
8674055 |
LDL receptor
related protein 2 |
LRP2 |
4036 |
n |
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*e-values are
shown for blastx searches against the Homo sapience genes. |
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**These genes
have the same nucleotide sequences. |
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***hh3, Pt-hh pRNAi stage3; hh5, Pt-hh pRNAi srage 5; ptc3,
Pt-ptc pRNAi
stage 3; ptc5, Pt-ptc pRNAi stage 5; +, up-regulated; -, down-regulated; n, not changed |
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