Parasteatoda tepidariorum counterparts of Hedgehog signaling genes

Table S1. Parasteatoda tepidariorum counterparts of Hedgehog signaling genes 
adapted from Akiyama-Oda and Oda, Sci. Adv. 6, eaba7261 (2020)
under a Creative Commons Attribution License 4.0 (CC BY 4.0)
  Parasteatoda tepidariorum   Drosophila melanogaster     Homo sapiens     Transcriptional response
Gene category aug3 gene model NCBI Gene ID e-value(blastx-Drosophila) Full Name Symbol NCBI Gene ID Full Name Symbol NCBI Gene ID to hh and ptc pRNAi***
hedgehog aug3.g4322 LOC107451809 5.00E-114 hedgehog hh 42737 Indian hedgehog signaling molecule IHH 3549 hh3(-), hh5(-)
  aug3.g5978 LOC107454029 3.00E-89     sonic hedgehog signaling molecule SHH 6469 n
        desert hedgehog signaling molecule DHH 50846  
patched aug3.g14374 LOC107440240 9.00E-132 patched ptc 35851 patched 1 PTCH1 5727 hh5(-), ptc3(-)
        patched 2 PTCH2 8643  
smoothened aug3.g8490 LOC107456312 6.00E-125 smoothened smo 33196 smoothened, frizzled class receptor SMO 6608 ptc5(+)
cubitus interruptus aug3.g13321 LOC107438714 7.00E-90 cubitus interruptus ci 43767 GLI family zinc finger 3 GLI3 2737 hh5(+), ptc5(-)
        GLI family zinc finger 2 GLI2 2736  
        GLI family zinc finger 1 GLI1 2735  
Suppressor of fused aug3.g4889 LOC107452674 3.00E-93 Suppressor of fused Su(fu) 41565 SUFU negative regulator of hedgehog signaling SUFU 51684 n
fused   fused fu 32855 serine/threonine kinase 36 STK36 27148  
Costal2   costa cos 35653 kinesin family member 27 KIF27 55582  
        kinesin family member 7 KIF7 374654  
Pka-C1 aug3.g8395 LOC107456224 0 Protein kinase, cAMP-dependent, catalytic subunit 1 Pka-C1 34284 protein kinase cAMP-activated catalytic subunit beta PRKACB 5567 n
  aug3.g19761 0     protein kinase cAMP-activated catalytic subunit alpha PRKACA 5566 n
GSK3B aug3.g9959 LOC107443254 0 shaggy sgg 31248 glycogen synthase kinase 3 beta GSK3B 2932 n
  aug3.g25394 LOC107441379 0         n
Casein kinase I aug3.g16082 LOC107441751 3.00E-169 Casein kinase Ialpha CkIalpha 32221 casein kinase 1 alpha 1   1452 n
  aug3.g14270 LOC107440109 1.00E-178 discs overgrown dco 43673 casein kinase 1 epsilon   1454 n
        casein kinase 1 delta   1453  
arrestin beta aug3.g2972 LOC107449817 0 kurtz krz 53554 arrestin beta 1 ARRB1 408 n
Gprk2 aug3.g279 LOC107452617 0 G protein-coupled receptor kinase 2 Gprk2 49045 G protein-coupled receptor kinase 5 GRK5 2869 hh3(+), hh5(-)
      G protein-coupled receptor kinase 6 GRK6 2870  
        G protein-coupled receptor kinase 4 GRK4 2868  
  aug3.g19133 LOC107446386 0 G protein-coupled receptor kinase 1 Gprk1 3355013 G protein-coupled receptor kinase 3 GRK3 157 n
        G protein-coupled receptor kinase 2 GRK2 156  
SPOP aug3.g12578 LOC107437781 0 roadkill rdx 41704 speckle type BTB/POZ protein SPOP 8405 n
Rab23 aug3.g27635 LOC107442385 3.00E-37 Rab23 rab23 40701 RAB23, member RAS oncogene family RAB23 51715 n
Talpid3       KIAA0586 KIAA0586 9786  
tectonic* aug3.g2815 LOC107449540 2.00E-27     tectonic family member 1 TCTN1 79600 n
  6.00E-27     tectonic family member 3 TCTN3 26123  
DZIP1 (iguana)       DAZ interacting zinc finger protein 1 DZIP1 22873  
slimb aug3.g5127 LOC107452997 0 supernumerary limbs slmb 42504 beta-transducin repeat containing E3 ubiquitin protein ligase BTRC 8945 n
  aug3.g13225 0     F-box and WD repeat domain containing 11 FBXW11 23291 n
Cullin 1 aug3.g1917 LOC107447770 0 Cullin 1 Cul1 35742 cullin 1 CUL1 8454 n
  aug3.g10620 0         n
Roc1a aug3.g6006 LOC107454093 2.00E-63 Regulator of cullins 1a Roc1a 31014 ring-box 1 RBX1 9978 n
Cullin 3 aug3.g4476 LOC107452044 0 Cullin 3 Cul3 34896 cullin 3 CUL3 8452 n
skinny hedgehog   rasp rasp 44098 hedgehog acyltransferase HHAT 55733  
tout-velu aug3.g3559 LOC107450714 0 tout-velu ttv 36614 exostosin glycosyltransferase 1 EXT1 2131 n
sister of tout-velu aug3.g12248 LOC107437365 0 Ext2 Ext2 3772101 exostosin glycosyltransferase 2 EXT2 2132 n
brother of tout-velu aug3.g6974 LOC107455291 0 brother of tout-velu botv 37198 exostosin like glycosyltransferase 3 EXTL3 2137 n
dispatched aug3.g10365 LOC107448433 7.00E-180 dispatched disp 44274 dispatched RND transporter family member 1 DISP1 84976 n
        dispatched RND transporter family member 2 DISP2 85455  
shifted aug3.g27568** LOC107442208 2.00E-47 shifted shf 31617 WNT inhibitory factor 1 WIF1 11197 hh5(+), ptc5(-)
  aug3.g24611** LOC107442208 7.00E-24         hh5(+), ptc5(-)
GAS1* aug3.g9575 LOC107438015 4.00E-14     growth arrest specific 1 GAS1 2619 hh5(+), ptc5(-)
dally aug3.g1222 LOC107446074 1.00E-56 division abnormally delayed dally 39013 glypican 5 GPC5 2262 n
dally-like aug3.g2730 LOC107449382 2.00E-77 dally-like dlp 39596 glypican 6 GPC6 10082 n
  aug3.g11833 LOC107436350 1.00E-55         hh5(-), ptc5(+)
interference hedgehog aug3.g12323 LOC107437450 9.00E-64 brother of ihog boi 31229 BOC cell adhesion associated, oncogene regulated BOC 91653 n
  9.00E-50 interference hedgehog ihog 33972 cell adhesion associated, oncogene regulated CDON 50937  
HHIP       hedgehog interacting protein HHIP 64399  
Megalin aug3.g9796 LOC107441084 0 Megalin mgl 8674055 LDL receptor related protein 2 LRP2 4036 n
*e-values are shown for blastx searches against the Homo sapience genes.
**These genes have the same nucleotide sequences.
***hh3, Pt-hh pRNAi stage3; hh5, Pt-hh pRNAi srage 5; ptc3, Pt-ptc pRNAi stage 3; ptc5, Pt-ptc pRNAi stage 5; +, up-regulated;  -, down-regulated; n, not changed